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2010 Fiscal Year Final Research Report

Brain function and epileptogenecity in human cortical dysplasias

Research Project

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Project/Area Number 20591713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSapporo Medical University (2010)
Kyoto University (2008-2009)

Principal Investigator

MIKUNI Nobuhiro  札幌医科大学, 医学部, 教授 (60314217)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  京都大学, 医学研究科, 准教授 (90212761)
MATSUMOTO Riki  京都大学, 医学研究科, 助教 (00378754)
Project Period (FY) 2008 – 2010
Keywordsてんかん / 脳機能 / 皮質形成異常
Research Abstract

We have studied the mechanisms underlying epileptogenesis in cortical dysplasia by using a rat model and a human specimen. The results have shown that excitatory postsynaptic NMDA receptors played a critical role of epilepsy associated with cortical dysplasia. To clarify the mechanisms of human epilepsy, we examined the total protein levels of both NR1 and calmodulin, as well as their coassembly in the human non-epileptogenic cortical areas compared to those in the epileptogenic cortical areas(ictal EEG seizure onset areas as determined by subdural grid electrode recordings). The coassembly of calmodulin and NMDAR1 was decreased in epileptogenic dysplastic cortex compared with normal appearing non-epileptogenic cortex, while there was no significant difference in the total protein levels of calmodulin or NMDAR1 between the two EEG groups. These results suggest that decreased calmodulin-NMDAR1 coassembly is a cellular mechanism that contributes to hyperexcitability in dysplastic cortical neurons and in focal seizure onsets. Reagarding the brain function, epileptic cortical dysplasia have language or motor function which could be compensated following resection.

  • Research Products

    (30 results)

All 2011 2010 2009 2008

All Journal Article (12 results) Presentation (13 results) Book (5 results)

  • [Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential2011

    • Author(s)
      Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO
    • Journal Title

      Hum Brain Mapp.

      Pages: 19

    • DOI

      doi:10.1002/hbm.21407.

  • [Journal Article] Ictal wideband ECoG : Direct comparison between ictal slow shifts and high frequency oscillations2011

    • Author(s)
      Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A
    • Journal Title

      Clin Neurophysiol

      Volume: 122(8) Pages: 1500-1504

  • [Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in thehuman motor system2011

    • Author(s)
      Kikuchi T, Matsumoto R, Mikuni N, Yokoyama Y, Matsumoto A, Ikeda A, Fukuyama H, Miyamoto S, Hashimoto N
    • Journal Title

      Clin Neurophysiol

      Pages: 26

  • [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy2011

    • Author(s)
      Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82(6) Pages: 652-657

  • [Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study2011

    • Author(s)
      Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fkuyama H, Takahashi R, Ikeda A
    • Journal Title

      Neuropsychologia

      Volume: 49 Pages: 1350-1354

  • [Journal Article] Intravenous methylprednisolone reduces the risk of propofol-induced adverse effects during Wada testing2010

    • Author(s)
      Mikuni N, Yokoyama Y, Matsumoto A, Kikuchi T, Yamada S, Hashimoto N, and S Miyamoto S
    • Journal Title

      Neurol Med Chir

      Volume: 50 Pages: 622-6

  • [Journal Article] 皮質形成異常の診断と外科治療2010

    • Author(s)
      三國信啓
    • Journal Title

      Epilepsy

      Volume: 4 Pages: 35-42

  • [Journal Article] 覚醒下手術と大脳機能局在2010

    • Author(s)
      三國信啓
    • Journal Title

      CLINICAL NEUROSCIENCE

      Volume: 28 Pages: 1115-1117

  • [Journal Article] 小児てんかんに対する外科的治療2010

    • Author(s)
      三國信啓
    • Journal Title

      脳神経外科ジャーナル

      Volume: 19 Pages: 321-331

  • [Journal Article] Postoperative quality of life outcome and employment in patients undergoing resection of epileptogenic lesions detected by magnetic resonance imaging2009

    • Author(s)
      Moritake K, Mikuni N, Akiyama Y, Nagai H, Maruyama N, Takada D, Daisu M, Nagasako N, Hashimoto N
    • Journal Title

      Neurol Med Chir

      Volume: 49(7) Pages: 281-286

  • [Journal Article] Negative motor seizure arising from the negative motor area : Is it ictal apraxia?2009

    • Author(s)
      Ikeda A, Hirasawa KI, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouchi M, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
    • Journal Title

      Epilepsia

      Volume: 50(9) Pages: 2072-84

  • [Journal Article] Long-term seizure outcome in patients undergoing resection of lesions detected by magnetic resonance imaging2008

    • Author(s)
      Moritake K, Mikuni N, Akiyama Y, Nagai H, Maruyama N, Takada D, Sugimoto K, Nagasako N, Hashimoto N.
    • Journal Title

      Neurol Med Chir

      Volume: 48 Pages: 546-51

  • [Presentation] ランチョンセミナー:てんかん外科治療の適応と実際2011

    • Author(s)
      三國信啓
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟
    • Year and Date
      2011-10-07
  • [Presentation] てんかんの手術について.2011

    • Author(s)
      三國信啓
    • Organizer
      日本てんかん協会北海道支部記念講演会
    • Place of Presentation
      旭川
    • Year and Date
      2011-04-24
  • [Presentation] てんかんの外科治療2011

    • Author(s)
      三國信啓
    • Organizer
      第13回北海道脳神経外科手術研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-02-19
  • [Presentation] Integrated functional neuronavigation during neurosurgery2010

    • Author(s)
      Mikuni N, Susumu M
    • Organizer
      ICCN
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-10-30
  • [Presentation] 脳神経外科疾患に伴うてんかんの治療戦略.2010

    • Author(s)
      三國信啓
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
  • [Presentation] 小児神経外科のABC.2010

    • Author(s)
      三國信啓
    • Organizer
      第38回日本小児神経外科学会
    • Place of Presentation
      富山
    • Year and Date
      2010-06-03
  • [Presentation] てんかん外科の進歩海馬切除術.2010

    • Author(s)
      三國信啓
    • Organizer
      第30回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-05-06
  • [Presentation] てんかんに対する覚醒下手術.2010

    • Author(s)
      三國信啓
    • Organizer
      第19回脳神経外科手術と機器学会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-20
  • [Presentation] 選択的扁桃体海馬切除術側頭下アプローチ.2010

    • Author(s)
      三國信啓
    • Organizer
      第33回てんかん外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-22
  • [Presentation] Epilepsy Surgery preserving functions.2009

    • Author(s)
      Mikuni N
    • Organizer
      The 2nd Korean-Japanese Epilepsy Society Symposium
    • Place of Presentation
      Hirosaki, Japan
    • Year and Date
      2009-10-23
  • [Presentation] 脳神経外科開頭手術後のてんかんに対する予防と治療.2009

    • Author(s)
      三國信啓
    • Organizer
      第43回日本てんかん学会
    • Place of Presentation
      弘前
    • Year and Date
      2009-10-22
  • [Presentation] 新皮質てんかんの外科治療.2009

    • Author(s)
      三國信啓
    • Organizer
      第50回京滋てんかん懇話会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-14
  • [Presentation] 新皮質てんかんにおける焦点同定と摘出のための検討.2009

    • Author(s)
      三國信啓
    • Organizer
      第32回てんかん外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-22
  • [Book] 腫瘍2011

    • Author(s)
      三國信啓
    • Total Pages
      253-260
    • Publisher
      南江堂
  • [Book] 機能的脳神経外科2011

    • Author(s)
      三國信啓
    • Total Pages
      327-340
    • Publisher
      医学書院
  • [Book] てんかん焦点診2010

    • Author(s)
      三國信啓
    • Total Pages
      1203-1213
    • Publisher
      シュプリンガージャパン
  • [Book] 側頭葉・後頭葉の手術後頭葉てんかんの手術2010

    • Author(s)
      三國信啓
    • Total Pages
      160-165
    • Publisher
      メジカルビュー社
  • [Book] 内側側頭葉てんかん:手術適応の判断基準と治療戦略は?2010

    • Author(s)
      三國信啓
    • Total Pages
      313-316
    • Publisher
      中外医学社

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Published: 2013-07-31  

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