2010 Fiscal Year Final Research Report
Brain function and epileptogenecity in human cortical dysplasias
| Project/Area Number |
20591713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University (2010)
Kyoto University (2008-2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Akio 京都大学, 医学研究科, 准教授 (90212761)
MATSUMOTO Riki 京都大学, 医学研究科, 助教 (00378754)
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| Project Period (FY) |
2008 – 2010
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| Keywords | てんかん / 脳機能 / 皮質形成異常 |
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| Research Abstract |
We have studied the mechanisms underlying epileptogenesis in cortical dysplasia by using a rat model and a human specimen. The results have shown that excitatory postsynaptic NMDA receptors played a critical role of epilepsy associated with cortical dysplasia. To clarify the mechanisms of human epilepsy, we examined the total protein levels of both NR1 and calmodulin, as well as their coassembly in the human non-epileptogenic cortical areas compared to those in the epileptogenic cortical areas(ictal EEG seizure onset areas as determined by subdural grid electrode recordings). The coassembly of calmodulin and NMDAR1 was decreased in epileptogenic dysplastic cortex compared with normal appearing non-epileptogenic cortex, while there was no significant difference in the total protein levels of calmodulin or NMDAR1 between the two EEG groups. These results suggest that decreased calmodulin-NMDAR1 coassembly is a cellular mechanism that contributes to hyperexcitability in dysplastic cortical neurons and in focal seizure onsets. Reagarding the brain function, epileptic cortical dysplasia have language or motor function which could be compensated following resection.
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Research Products
(30 results)
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[Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential2011
Author(s)
Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO
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Journal Title
Hum Brain Mapp.
Pages: 19
DOI
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[Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study2011
Author(s)
Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fkuyama H, Takahashi R, Ikeda A
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Journal Title
Neuropsychologia
Volume: 49
Pages: 1350-1354
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[Journal Article] Negative motor seizure arising from the negative motor area : Is it ictal apraxia?2009
Author(s)
Ikeda A, Hirasawa KI, Kinoshita M, Hitomi T, Matsumoto R, Mitsueda T, Taki JY, Inouchi M, Mikuni N, Hori T, Fukuyama H, Hashimoto N, Shibasaki H, Takahashi R
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Journal Title
Epilepsia
Volume: 50(9)
Pages: 2072-84
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