2010 Fiscal Year Final Research Report

Neurochemical study for post-operative delirium

Research Project

Project/Area Number	20591839
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Fukushima Medical University
Principal Investigator	MURAKAWA Masahiro Fukushima Medical University, 医学部, 病院長 (90182112)
Research Collaborator	NEMOTO Chiaki 福島県立医科大学, 医学部, 助教 (30443865) HAKOZAKI Takahiro 福島県立医科大学, 医学部, 大学院生 (60595429) AOKI Ken-ichi 福島県立医科大学, 医学部, 大学院研究生 HIRAMA Takahiro 福島県立医科大学, 医学部, 大学院研究生 KANNO Ryoko 福島県立医科大学, 医学部, 主任医療技師
Project Period (FY)	2008 – 2010
Keywords	術後せん妄 / 吸入麻酔薬 / 鎮静薬 / 手術ストレス / アセチルコリン / 脳内微小透析法
Research Abstract	To clarify the neurochemical basis for postoperative delirium, the changes of acetylcholine release in rat cerebral cortex by the painful stimulation during general anesthesia and by the sedation were studied using brain microdialysis. The acetylcholine release was significantly affected by widely-used inhalational anesthetics and sedatives. The results of this study suggest that the occurrence of post-operative delirium is related to the changes in cholinergic neuronal activities in the brain.

(2 results)