2010 Fiscal Year Final Research Report
The molecular mechanism of Actinin-4 in proliferation, invasion and metastasis of cancer
| Project/Area Number |
20591857
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKATSUJI Hiroyoshi The University of Tokushima, 病院, 助教 (50437638)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA HiroーOmi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10214446)
TAKAHASHI Masayuki 徳島大学, 病院, 講師 (50325255)
FUKUMORI Tomoharu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10314874)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Actinin4 / 泌尿器癌 / 浸潤 |
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| Research Abstract |
Actinin-4 mRNA and protein levels are elevated in bladder cancer cells lines that exhibit increased growth and invasion activity. In addition, actinin-4 knockdown inhibited invasion of bladder cancer cells, but did not alter their growth. In conclusion, we hypothesize that the accumulation of actinin-4 in the cell cytoplasm, rather than its recruitment to the cell membrane, is related to an increased susceptibility of tumor invasion and metastasis.
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