2010 Fiscal Year Final Research Report
Transdifferentiation induction of murine epidermal SP cells into corneal epithelial cells.
| Project/Area Number |
20592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Ehime University |
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Principal Investigator |
SHIRAISHI Atsushi Ehime University, 大学院・医学系研究科, 寄附講座准教授 (90314963)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 愛媛大学, 大学院・医学系研究科, 寄附講座助教 (70380285)
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| Co-Investigator(Renkei-kenkyūsha) |
OHASHI Yuichi 愛媛大学, 大学院・医学系研究科, 教授 (00116005)
SHIRAKATA Yuji 愛媛大学, 大学院・医学系研究科, 講師 (50226320)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 眼発生 / 再生医学 |
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| Research Abstract |
In the present study, we investigated the potential for murine epidermal cells transdifferentiation into corneal epithelial-like cells, and demonstrate that murine epidermal cells have the potential to transdifferentiate into corneal epithelial-like cells. The results indicate that transdifferentiation may require the effect of coculture with corneal epithelial cells, as well as the corneal limbal environment.
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[Journal Article] Lumican is required for neutrophil extravasation following corneal injury and wound healing.2010
Author(s)
Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW.
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Journal Title
J Cell Sci. 123(Pt17)
Pages: 2987-2995
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[Remarks] ホームページ等
