2010 Fiscal Year Final Research Report
New procedure of evaluation of molecular mechanism in skin cancer : adequate diagnosis and reconstruction.
| Project/Area Number |
20592099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
MORI Hideki Ehime University, 医学部附属病院, 助教 (60325389)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAKAWA Satoshi 愛媛大学, 医学部附属病院, 講師 (50419511)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リンパ管新生 / Paget病 |
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| Research Abstract |
In extramammary Paget disease(EMPD), lymphangiogenesis appeared in a early stage. We found that Paget cells adopt an invasive phenotype during epithelial-mesenchymal transition (EMT) seen in tumor progression. We found that invasive Paget cells in patient N-cadherin, a mesenchymal marker indicative of EMT, suggesting a molecular mechanism underlying tumour invasion. EMT is reportedly required for invasive phenotypes of tumour cells of epithelial origin, including EMPD.
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