2010 Fiscal Year Final Research Report
The pathogenic mechanisms of peripheral nerve disorders associated with severe sepsis -A study of the protective effect of X factor inhibitor-
| Project/Area Number |
20592130
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | St.Marianna University School of Medicine |
|---|
Principal Investigator |
HINO Hirofumi St.Marianna University School of Medicine, 医学部, 准教授 (70308500)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 敗血症 / 人工呼吸器離脱困難症 / 末梢神経炎 / 第Xa因子阻害薬 |
|---|
| Research Abstract |
Although peripheral nerve disorders are associated with sepsis, the pathogenic mechanisms involved have yet to be clarified and treatment is not well established. Our data demonstrated that increase of rheobase without electro-microscopic degeneration implied that alteration of threshold, rather than degenerative changes, might develop in peripheral nerve tissue in the early phases of sepsis. This suggests the possibility that these factors are likely to be associated with peripheral nerve disorders such as critical illness polyneuropathy. Furthermore, since the combined effect of danaparoid and antithrombin3 resulted in clinical improvement, our data suggests that it might significantly affect the medical treatment of severe peripheral neuropathy associated with sepsis.
|
