The role of mobile genetic elements in Porphyromonas gingivalis strain diversity

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: NAITO Mariko Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (20244072)
• Co-Investigator(Renkei-kenkyūsha): SHOJI Mikio 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10336175)
• Project Period (FY): 2008 – 2010
• Keywords: 口腔細菌学

Research Abstract

We revealed that periodontal pathogen, Porphyromonas gingivalis, has the extensive genomic diversity among the strains. CTnPg1 is one of the mobile genetic elements in P.gingivalis. This study shows that CTnPg1 can be transferred between P. gingivalis strains and other bacterial species. These results suggest that CTnPg1 may play important roles for the acquisition of diversity within bacterial species and the adaptability against oral environment.

Research Products

• [Journal Article] A protein secretion system linked to bacteroidete gliding motility and pathogenesis. (2010)
  • Author(s): Sato K, Naito M, Yukitake H, Hirakawa H, Shoji M, McBride MJ, Rhodes RG, Nakayama K
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P.gingivalis. (2008)
  • Author(s): Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, Nakayama K, Toh H, Yoshimura F, Kuhara S, Hattori M, Hayashi T, Nakayama K.
  • Journal Title: DNA Res. 15(4) Pages: 215-225
  • URL: http://naosite.lb.nagasaki-u.ac.jp/dspace/handle/10069/20817
  • Peer Reviewed
• [Presentation] Porphyromonas gingivalisのconjugative transposon CTnPg1の伝達機構の解析 (2010)
  • Author(s): 内藤真理子, 佐藤啓子, 雪竹英治, 庄子幹郎, 中山浩次
  • Organizer: 第52回歯科基礎医学会学術大会ならびに総会{Journal of Oral Biosciences, 52, Supp.l, p185}
  • Place of Presentation: 東京
  • Year and Date: 20100900
• [Presentation] Porphyromonas gingivalisのconjugative transposon CTnPg1の伝達機構の解析 (2010)
  • Author(s): 内藤真理子, 佐藤啓子, 雪竹英治, 庄子幹郎, 中山浩次
  • Organizer: 第4回日本ゲノム微生物学会年会{プログラムおよび講演抄録集p59}
  • Place of Presentation: 福岡
  • Year and Date: 20100300
• [Presentation] Characterization of Porphyromonas gingivalis Conjugative Transposon CTnPg1. (2010)
  • Author(s): Naito M, Sato K, Shoji M, Yukitake H, Hayashi T, Nakayama K
  • Organizer: 88th IADR, Barcelona, {Program, pp160}
  • Place of Presentation: Spain
  • Year and Date: 20100000
• [Presentation] Porphyromonas gingivalisのtransposon CTnPg1の伝達機構 (2009)
  • Author(s): 内藤真理子, 佐藤啓子, 雪竹英治, 庄子幹郎, 林哲也, 中山浩次
  • Organizer: 第3回日本ゲノム微生物学会年会{要旨集,p.59}
  • Place of Presentation: 東京
  • Year and Date: 20090300
• [Presentation] Porphyromonas gingivalisの接合による遺伝子形質の伝達 (2008)
  • Author(s): 内藤真理子, 佐藤啓子, 雪竹英治, 庄子幹郎, 中山浩次
  • Organizer: 第50回歯科基礎医学会学術大会ならびに総会{Journal of Oral Biosciences, 50, Suppl., p218}
  • Place of Presentation: 東京
  • Year and Date: 20080900
• [Remarks] ホームページ等