2010 Fiscal Year Final Research Report
Therapeutic strategies against bone resorption using calcineurin signaling in osteoclast
| Project/Area Number |
20592172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
SAEKI Makio Osaka University, 大学院・歯学研究科, 講師 (30273692)
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| Co-Investigator(Kenkyū-buntansha) |
KAMISAKI Yoshinori 大阪大学, 大学院・歯学研究科, 教授 (40116017)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 破骨細胞 / NFATc1 / スクリーニング / 小分子化合物 / harmine / id2 |
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| Research Abstract |
Small molecular compounds that potently affect osteoclastogenesis could be useful as a chemical probe for elucidating the mechanism of biological phenomena and form the basis for effective therapeutic strategies against bone resorption. To establish a high-throughput screening system for identifying osteoclastogenesis-related compounds using a cell-based sensor, and to identify novel chemical entities regulating signaling pathways in osteoclasts. Harmine activates NFATc1 expression independent of RANKL stimulation, as well as enhanced Id2 expression in osteoclast precursor cells. These multimodal actions of harmine may overall suppress osteoclastogenesis.
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Research Products
(20 results)
