2010 Fiscal Year Final Research Report
Imaging analysis of the electrolyte transport and protein secretions in salivary ducts to reveal their regulatory mechanisms
| Project/Area Number |
20592180
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORITA Takao 北海道医療大学, 歯学部, 講師 (20326549)
NEZU Akihiro 北海道医療大学, 歯学部, 講師 (00305913)
TOJYO Yosuke 北海道医療大学, 歯学部, 教授 (90111731)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 歯科薬理学 |
|---|
| Research Abstract |
Using multiphoton microscopy, the present study established that rat salivary ductal cells exhibit spontaneous oscillations in intracellular Ca^<2+> concentration([Ca^<2+>] i). Pharmacological examinations indicate that purinergic receptors play major roles in these spontaneous Ca2+oscillations. It was also found that spontaneous elevations of[Ca^<2+>] i were well correlated with spontaneous cell swelling of ductal cells. These results indicate the possibility that the Ca^<2+> oscillations are induced by the spontaneous ATP release in salivary ductal cells in the resting state and regulate electrolyte reabsorption.
|
