Bone metabolic activity around dental implants observed using fine PET

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592255
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Tohoku University
• Principal Investigator: KUBO KEI Tohoku University, 大学院・歯学研究科, 大学院非常勤講師 (10431511)
• Co-Investigator(Kenkyū-buntansha): SASAKI Keiichi 東北大学, 大学院・歯学研究科, 教授 (30178644) ; YOKOYAMA Masayoshi 東北大学, 大学院・歯学研究科, 助教 (20396500)
• Project Period (FY): 2008 – 2010
• Keywords: インプラント / 骨代謝 / 定量評価 / PET / FEM

Research Abstract

This study aimed to examine the influence of early loading on dynamic changes of bone metabolism around dental implants by using a Fine PET. Two titanium implants were inserted in the right tibiae of Wistar rats. 1 day after insertion, closed coil springs with 4.0 N were applied to the implants. The rats with 18F-(5mCi/rat) intravenously-injected were scanned by PET scanner at 4, 7, 14, 28 days after load application. Round ROIs were set around the distal implant (right tibia) and at the intact side (left tibia). Longitudinal dynamic changes in bone metabolism were evaluated by examination of the accumulation count of 18F-at each ROI. The results shows that early loading to the implant initially enhanced the bone metabolism around the implant, however, metabolic activity returned to pre-loading level with time despite a static force being applied to the implants.

Research Products

• [Journal Article] Bone metabolic activity around dental implants under loading observed using bone scintigraphy (2008)
  • Author(s): Sasaki H, Koyama S, Yokoyama M, Yamaguchi K, Itoh M, Sasaki K
  • Journal Title: The International Journal of Oral & Maxill of acial Implants 23 Pages: 827-834
  • Peer Reviewed
• [Presentation] Influence of early loading on bone metabolic activity around dental implants (2010)
  • Author(s): M.Yamamoto, M.Yokoyama, S.Koyama, H.Sasaki, Y.Funaki, Y.Kikuchi, H.Yamazaki, K.Ishii, K.Sasaki
  • Organizer: IADR GENERAL SESSION 2010
  • Place of Presentation: Center Convencions International Barcelona Spain
  • Year and Date: 20100714-20100717
• [Presentation] 即時荷重,早期荷重負荷の相違がインプラント周囲骨代謝活性に及ぼす影響 (2009)
  • Author(s): 山本未央,横山政宣,小山重人,佐々木洋人,佐々木啓一
  • Organizer: 第39回日本口腔インプラント学会学術大会大阪国際会議場
  • Place of Presentation: 大阪
  • Year and Date: 20090925-20090927
• [Presentation] 窒素含有bisphosphonateの骨との結合におよぼすetidronateの効果に関する分子イメージング的検討 (2009)
  • Author(s): 山本未央,横山政宣,高橋春江,遠藤康男,佐々木啓一
  • Organizer: 第51回歯科基礎医学会学術大会(講演要旨集P117)
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(新潟)
  • Year and Date: 20090909-20090911
• [Presentation] 高解像度PETを用いた即時,早期荷重負荷時の歯科インプラント周囲骨代謝活性に関する研究 (2009)
  • Author(s): 山本未央,横山政宣,佐々木洋人,小山重人,船木善仁,菊池洋平,中村賢司,中沢浩一,山崎浩道,石井慶造,佐々木啓一
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台国際センター(仙台)
  • Year and Date: 2009-06-16
• [Presentation] Imaging of Bone Metabolism-Nuclear Medicine Approach Using Fine PET- (2009)
  • Author(s): 山本未央,横山政宣,佐々木洋人,小山重人,船木善仁,菊池洋平,中村賢司,中沢浩一,山崎浩道,石井慶造,佐々木啓一
  • Organizer: 第1回半導体PETカメラワークショップ/ユーザーズミーティング
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
  • Year and Date: 2009-04-25
• [Presentation] 即時荷重負荷後のインプラント周囲骨代謝活性-骨シンチグラフィを用いた核医学的な評価- (2008)
  • Author(s): 横山政宣、山本未央、佐々木洋人、小山重人、佐々木啓一
  • Organizer: 第28回(社)日本口腔インプラント学会東北・北海道支部総会・学術大会
  • Place of Presentation: 仙台情報・産業プラザ
  • Year and Date: 20081011-20081012
• [Book] Interface Oral Health Science(Evaluation of Bone Metabolism of Temporomandibular Joint by using high resolution PET scanner.) (2010)
  • Author(s): M.Yamamoto, M.Yokoyama, S.Koyama, Y.Funaki, Y.Kikuchi, K.Nakamura, K.Nakazawa, H.Yamazaki, K.Ishii, K.Sasaki
  • Total Pages: 190-192
  • Publisher: Springer