2010 Fiscal Year Final Research Report
Isolation and identification of the NALP3- and IPAF-ligands
| Project/Area Number |
20599014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
OGURA Yasunori University of the Ryukyus, 大学院・医学研究科, 助教 (60304557)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 感染免疫 / Caspase-1 / NALP3(NLRP3) / IPAF(NLRC4) / Danger signal |
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| Research Abstract |
The NALP3 and IPAF proteins are known to induce inflammation. In this study, I attempted to identify the factors that directly activate NALP3 and IPAF. Although I could not isolate such factors during this period, I revealed many important features in the chemical process of the NALP3 activation. On the basis of these findings, I will continue searching the NALP3- and IPAF-ligands.
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[Journal Article] Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.2010
Author(s)
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Nunez G, Suzuki T.
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Journal Title
J Immunol. 184
Pages: 5287-5297
Peer Reviewed
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