2010 Fiscal Year Final Research Report
The effects of IL-35 on periodontal diseases
| Project/Area Number |
20599020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
KOGOE Nahoko Hyogo College of Medicine, 薬学部, 助手 (60509115)
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| Co-Investigator(Kenkyū-buntansha) |
OHYAMA Hideki 兵庫医科大学, 医学部, 准教授 (90280685)
TERADA Nobuyuki 兵庫医科大学, 医学部, 教授 (50150339)
NAKASYO Keiji 兵庫医科大学, 医学部, 教授 (00217712)
YAMADA Naoko 兵庫医科大学, 医学部, 講師 (10319858)
YAMANEGI Koji 兵庫医科大学, 医学部, 講師 (00434944)
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| Project Period (FY) |
2008 – 2010
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| Keywords | IL-35 / 歯周病 / 制御性T細胞 |
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| Research Abstract |
The objective of this study is to elucidate the implication of IL-35, a recently identified member of the IL-12 family of cytokines, in the pathogenesis of periodontal diseases. Firstly, we examined the gene expression of IL-35 in periodontal lesions. IL-35 is a heterodimeric protein consisting of IL-12・ and IL-27・ chain, which are encoded by two separate genes called IL12A and EBI3, respectively. When comparing to gene expression levels of EBI3 and IL12A in lesional sites and control sites, we found that the relative level of gene expression for EBI3 and IL12A was significantly higher at lesional sites than at control sites. Moreover, we found that the relative gene expression ratio of EBI3 to IL12A showed significant difference in Th cells derived from periodontal lesions and peripheral blood when activated with anti-CD3/CD28 beads. From these findings, IL-35 might be implicated in the pathogenesis of periodontal diseases.
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Research Products
(4 results)
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[Journal Article] Fibroblasts stimulated via HLA-II molecules produce prostaglandin E_2 and regulate cytokine production from helper T cells.2010
Author(s)
Kato-Kogoe N, Ohyama H, Nishimura F, Meguro M, Yoshizawa S, Okada Y, Nakasho K, Yamanegi K, Yamada N, Hata M, Higashi T, Terada N, Matsushita S.
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Journal Title
Lab Invest. 90(12)
Pages: 1747-56
Peer Reviewed
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