2010 Fiscal Year Final Research Report
Regulation of pain transmission by a neuropeptide nocistatin binding protein.
| Project/Area Number |
20602011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ASHITAKA Emiko Kansai Medical University, 工学部, 教授 (50291802)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経因性疼痛 / アロディニア / 炎症性疼痛 / 遺伝子欠損マウス / ノシスタチン / ノシスタチン結合タンパク質 |
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| Research Abstract |
The neuropeptide nocistatin has inhibitory effects on chronic pain after nerve injury and inflammation. We identified a protein (Nocistatin binding protein, NSP) that interacted with nocistatin from synaptosomal membranes of mouse spinal cord. Nocistatin interacted with the N-terminal truncated form of 29-kDa NSP that was ubiquitously expressed in neural tissues. The inhibition of tactile allodynia by nocistatin seen in wild-type mice was completely lacking in NSP-deficient mice, and the inflammatory pain was prolonged in the deficient mice.
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[Journal Article] Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.2008
Author(s)
Moriuchi H., Koda N., Okuda-Ashitaka E., Daiyasu H., Ogasawara K., Toh H., Ito S., Woodward, D.F., Watanabe K.
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Journal Title
J Biol.Chem. 283
Pages: 792-801
Peer Reviewed
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[Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.2008
Author(s)
Takagi K., Okuda-Ashitaka E., Mabuchi T., Katano T., Ohnishi T., Matsumura S., Ohnaka M., Kaneko S., Abe T., Hirata T., Fujiwara S., Minami T., Ito S.
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Journal Title
Neuroscience 153
Pages: 1278-1288
Peer Reviewed
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