2010 Fiscal Year Final Research Report
Activated mechanism in the neuroplasticity change of nitric oxide, which is a diagnosis and the candidate of the treatment index
| Project/Area Number |
20602012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ABE Tetsuya Kansai Medical University, 医学部, 講師 (20411506)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
FUKUNAGA Mikihiko 関西医科大学, 医学部, 教授 (90257949)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性疼痛 / 一酸化窒素 / 神経可塑生 / 脊髄 / 後根神経節 / グルタミン酸 / NMDA受容体 |
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| Research Abstract |
Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects million of people worldwide. Fyn kinase-mediated phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 in the dorsal horn may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase. Y1472F-KI mice witha knock-in mutation of the Tyr1472 site to phenylalanine did not exhibit neuropathic pain induced by L5 spinal nerve transection.
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[Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.2008
Author(s)
Takagi K, Okuda-Ashitaka E, Mabuchi T, Katano T, Ohnishi T, Matsumura S, Ohnaka M, Kaneko S, Abe, T, Hirata T, Fujiwara S, Minami T, Ito S
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Journal Title
Neuroscience 153
Pages: 1278-1288
Peer Reviewed
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