2010 Fiscal Year Final Research Report
Synthesis and properties of 4'-selenoRNA based on biological equivalence
| Project/Area Number |
20611001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAKAWA Noriaki Hokkaido University, 大学院・ヘルスバイオサイエンス研究部, 教授 (40209820)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ヌクレオシド / RNA / 4'-セレノRNA / 生物学的等価性 / セレン |
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| Research Abstract |
In this work, I aimed to prepare a new chemically modified RNA molecule exhibiting a biological equivalence with natural RNA. To be concrete, 4'-selenoRNA and 2'-OMe-4'-selenoRNA, in which the furanose ring oxygen is replaced by a seleno atom, were prepared and their properties were examined. Accordingly, these RNA molecules showed a higher hybridization property and nuclease resistance.
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Research Products
(13 results)
