2011 Fiscal Year Final Research Report
Studies on the physiological or pathological neuronal regulation based on the receptor dynamics and calcium signals
| Project/Area Number |
20700300
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
BANNAI Hiroko 独立行政法人理化学研究所, 発生神経生物研究チーム, 研究員 (40332340)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 抑制性シナプス / カルシウム / GABA_A受容体 / 1分子イメージング / 量子ドット / シナプス可塑性 |
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| Research Abstract |
The mobility of the neurotransmitter receptors on the plasma membrane is one of the factors determining the efficacy of synaptic transmission. In this study, we found that the increase in GABA_A receptor lateral diffusion, which is induced by Ca^<2+> influx from the extracellular space and subsequent the activation of calcineurin, is the starting point of inhibitory synaptic plasticity. Our result also suggested the possibility that Ca^<2+> release from the intracellular Ca^<2+> store contributes to the inhibition of GABA_A receptor lateral diffusion through protein phosphorylation.
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