2011 Fiscal Year Final Research Report
Molecular systems underlying the regulation of anaphase-promoting complex/cyclosome ubiquitin ligase activity
| Project/Area Number |
20710178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHOJI Shisako 独立行政法人理化学研究所, システム研究チーム, 研究員 (60321808)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 細胞周期 / ユビキチン化反応 / APC/サイクロソーム / タンパク質複合体 / Emi2 |
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| Research Abstract |
Anaphase-promoting complex or cyclosome(APC/C) is a multi-subunit ubiquitin ligase that marks the target cell cycle regulators for proteasomal degradation. Emi2 was identified to be an essential component of the cytostatic factor, which antagonizes APC/C function in unfertilized vertebrate eggs. This study revealed the presence of the ubiquitin chain extension-interfering region within mouse Emi2.We propose a novel model for APC/C regulation, which differs from the previously reported mechanisms to block substrate recognition.
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