2010 Fiscal Year Final Research Report
Molecular Mechanisms about Changes of Cell Membranes Functions : Induced by Shear Forces
| Project/Area Number |
20760114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fluid engineering
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| Research Institution | Osaka University |
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Principal Investigator |
KOSHIYAMA Kenichiro Osaka University, 基礎工学研究科, 助教 (80467513)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞膜 / 超音波 / キャビテーション / ドラッグデリバリー |
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| Research Abstract |
We developed more realistic molecular model of cell membranes and obtained their physical characters by conducting molecular simulations of cell membranes composed of different types of lipids and cholesterol. The application of shear stresses to the cell membrane model revealed, for example, that the inclusion of cholesterol hampers the thinning the membrane. Furthermore, we found that the water penetration into the membrane caused by such stresses can induce spontaneous formation of a pore structure in the membrane.
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