2010 Fiscal Year Final Research Report
Gonadal function control mechanism in the pituitary gland through long-chain fatty acids as signal molecules.
| Project/Area Number |
20780202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | Kinki University |
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Principal Investigator |
MORIYAMA Ryutaro Kinki University, 理工学部, 講師 (30411573)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 下垂体 / 性腺刺激ホルモン産生細胞 / 脂肪酸 / 低栄養 / 性腺機能 / GPR120 / GnRH / 生殖 |
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| Research Abstract |
Present study showed that long-chain fatty acids such as palmitate may directly activate long-chain fatty acid receptor, GPR120, and down-regulate the synthesis of gonadotropin-releasing hormone receptors on gonadotrophs of the mouse pituitary gland as signal molecules. Moreover, it became clear that GPR120 expression levels were controlled by estrogen on the pituitary gland.
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Research Products
(11 results)
