2009 Fiscal Year Final Research Report
Effects of diphenylarsinic acid on the cerebellar glutaminase activity
| Project/Area Number |
20790113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
KITA Kayoko Teikyo University, 薬学部, 助教 (30407887)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ジフェニルアルシン酸 / グルタミナーゼ / 小脳 / 運動試験 |
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| Research Abstract |
To investigate the relationship between the diphenylarsinic acid(DPAA)-induced cerebellar dysfunction and glutaminase downregulation, the cerebellar phosphate-activated glutaminase(PAG) activities and GLS1 expression levels were examined. DPAA induced the impairment in motor coordination toward the almost all mice which were orally administrated DPAA for 36 days. However, no significant changes were observed in cerebellar PAG activities and GLS1 levels. These results suggested that glutaminase was not involved in the DPAA-induced cerebellar dysfunction.
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