2009 Fiscal Year Final Research Report
Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts
| Project/Area Number |
20790149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
TAKEDA Shuso Hokuriku University, 薬学部, 講師 (00460379)
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| Research Collaborator |
渡辺 和人 北陸大学, 薬学部, 教授 (30113038)
山本 郁男 九州保健福祉大学, 薬学部, 教授 (50069746)
山折 大 北陸大学, 薬学部, 助教 (40360218)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 大麻草 / カンナビノイド / 乳がん / テトラヒドロカンナビノール |
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| Research Abstract |
In the United States, THC has been used as medicine for patients suffering from heavy pan. We investigated whether or not THC, having a structure resembling estrogen, can affect estrogen-induced breast cancer progression. Although the action of estrogen was interfered with THC, in the low estrogen condition, breast cancer cell growth was stimulated by THC. Thus, it is suggested that there is an interaction between THC and estrogen, and that the action of THC might be influenced by the estrogen contents in the breast tissues.
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[Journal Article] Cannabidiol-2', 6'-Dimethylether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor2009
Author(s)
Takeda, S., Usami, N., Yamamoto, I., Watanabe, K.
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Journal Title
Drug Metab. Dispos. 37
Pages: 1733-1737
Peer Reviewed
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[Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling2008
Author(s)
Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K.
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Journal Title
Toxicology 245
Pages: 141-146
Peer Reviewed
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