2009 Fiscal Year Final Research Report
Senescence and maintenance mechanism of antigen-specific CD8+ T cells upon repeatitive antigenic challenges.
| Project/Area Number |
20790369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURACHI Makoto The University of Tokyo, 大学院・医学系研究科, 助教 (00396722)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 免疫記憶 / 老化 / CD8陽性T細胞 / 二次リンパ組織 |
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| Research Abstract |
Although it is suggested that the nature of memory CTL changes over repeated antigenic challenges, molecular characteristics of distinct memory CTL with different number of antigen experience are largely unknown. In this study, we analyzed genome wide transcriptome of primary and secondary memory CTL using a next-generation DNA sequencer. Memory CTL changes molecular signature as they experience the responses and memory CTL senescence differs from exhaustion.
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