2009 Fiscal Year Final Research Report
Expression and function of claudins in Aire expressing medullary thymic epithelial cells
| Project/Area Number |
20790373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
HAMAZAKI Yoko Kyoto University, 医学研究科, 助教 (10362477)
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| Project Period (FY) |
2008 – 2009
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| Keywords | T細胞分化 / 胸腺 / 上皮細胞 |
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| Research Abstract |
The thymus is a central lymphoid organ crucial for developing T cells. Aire is involved in expressing promiscuous gene expression of various tissue specific antigens in thymic stromal cells, which enables self-reactive T cells to be deleted in the thymus. In the previous study, we demonstrated that cell-adhesion molecules, claudins, are specifically expressed in Aire+ stromal cells. In this study, we produced claudin-KO mice to analyze the function of claudins on inducing self tolerance or development of Aire+ stromal cells.
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Research Products
(12 results)
