2009 Fiscal Year Final Research Report
Expression and function of claudins in Aire expressing medullary thymic epithelial cells
| Project/Area Number |
20790373
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HAMAZAKI Yoko Kyoto University, 医学研究科, 助教 (10362477)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | T細胞分化 / 胸腺 / 上皮細胞 |
|---|
| Research Abstract |
The thymus is a central lymphoid organ crucial for developing T cells. Aire is involved in expressing promiscuous gene expression of various tissue specific antigens in thymic stromal cells, which enables self-reactive T cells to be deleted in the thymus. In the previous study, we demonstrated that cell-adhesion molecules, claudins, are specifically expressed in Aire+ stromal cells. In this study, we produced claudin-KO mice to analyze the function of claudins on inducing self tolerance or development of Aire+ stromal cells.
|
