2010 Fiscal Year Final Research Report
Identification of a biomarker for the chronic fatigue syndrome
| Project/Area Number |
20790476
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Osaka City University |
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Principal Investigator |
IKEJIMA Nobue (獅子王 信江) Osaka City University, 大学院・医学研究科, 博士研究員 (50420401)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ストレス科学 |
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| Research Abstract |
Biological markers for chronic fatigue syndrome (CFS) have long been sought. In animal model for chronic stress, hyper-activation of melanotroph in pituitary gland and the increase of alpha-melanocyte stimulating hormone (α-MSH) level in plasma were demonstrated. In this regard an increase of α-MSH level in plasma of CFS patients who suffer from prolonged stress may be expected. We therefore examined α-MSH levels in CFS patients. CFS patients who suffer less than 5 years had significantly higher levels of α-MSH in their peripheral blood. The α-MSH could be a potent biological marker to diagnose CFS at least during the first 5 years from the onset.
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