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2009 Fiscal Year Final Research Report

Establishment of mouse model of human cryoglobulinemic glomerulonephritis

Research Project

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Project/Area Number 20790590
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKanazawa University

Principal Investigator

ITO Kiyoaki  Kanazawa University, 附属病院, 医員 (10467110)

Project Period (FY) 2008 – 2009
Keywordsクリオグロブリン / 糸球体腎炎 / ハイブリドーマ / モデルマウス / リウマトイド因子
Research Abstract

The purpose of our study is to establish a mouse model of cryoglobulinemic (Cryo) glomerulonephritis (GN). We established the hybridoma cell line producing IgM-kappa cryoglobulin with rheumatoid factor activity (Cryo+IgM RF) from a patient with Cryo GN. We administered Cryo+IgM RF to wild type Balb/c mice. Urinary albumin increased. Pathological analysis of kidney tissue showed mild endocapillary proliferation, mild mesangial cell proliferation, and deposition of Cryo+IgM RF in the glomeruli. These results provide basic data for the establishment of Cryo GN although renal pathological changes are mild.

  • Research Products

    (1 results)

All 2009

All Presentation (1 results)

  • [Presentation] Somatic hypermutation and intraclonal diversity in monoclonal IgM rheumatoid factor in mixed cryoglobulinemia.2009

    • Author(s)
      Kazunori Yamada, Mitsuhiro Kawano, Ryo Inoue, Hiroshi Fujii, Kiyoaki Ito, Ryoko Hamano, Yasushi Kakuchi, Masami Matsumura, Ichiro Koni, Akihiro Yachie, Masakazu Yamagishi.
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan Convention Center, Milan, Italy
    • Year and Date
      20090522-20090526

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Published: 2012-02-13   Modified: 2016-04-21  

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