Podocyte-protective effects of vitamin D

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: MATSUI Isao Osaka University, 医学系研究科, 助教 (60456986)
• Project Period (FY): 2008 – 2009
• Keywords: 糸球体上皮細胞 / vitamin D / 慢性腎臓病

Research Abstract

We have proved that active vitamin D and its analogue 22-oxacalcitriol protect podocytes from injury in puromycin aminonucleoside induced nephrosis rats. Because podocyte injuries and resultant proteinuria are major risk factors in chronic kidney disease (CKD), our finding provides new therapeutic strategy for the prevention of CKD.

Research Products

• [Journal Article] ビタミンDの腎保護作用 (2010)
  • Author(s): 松井功
  • Journal Title: 医学のあゆみ 233巻3号 Pages: 256
• [Journal Article] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats (2009)
  • Author(s): Isao Matsui, Takayuki Hamano, Kodo Tomida, Kazunori Inoue, Yoshitsugu Takabatake, Yasuyuki Nagasawa, Noritaka Kawada, Takahito Ito, Hiroshi Kawachi, Hiromi Rakugi, Enyu Imai, Yoshitaka Isaka
  • Journal Title: Nephrol Dial Transplant 24(8) Pages: 2354-61
  • Peer Reviewed
• [Presentation] Maxacalcitol ameliorates kidney injury in Dahl salt-sensitive rats in a rennin-independent manner (2010)
  • Author(s): Kazunori Inoue, Isao Matsui, Chikako Nakano, Yoshitaka Isaka, Hiromi Rakugi
  • Organizer: ISN NEXUS
  • Place of Presentation: Kyoto
  • Year and Date: 2010-04-16
• [Presentation] Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside -induced nephrosis in rats (2009)
  • Author(s): Isao Matsui
  • Organizer: ROD-21研究会
  • Place of Presentation: 船橋
  • Year and Date: 2009-09-05
• [Presentation] ビタミンDはネフローゼラソトの尿蛋白を減少させる (2008)
  • Author(s): 松井功、濱野高行、三上聡司、冨田弘道、田中啓隆、猪阪善隆、伊藤孝仁、今井圓裕、楽木宏実
  • Organizer: 日本腎臓学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-31
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/basicresearch.html