2009 Fiscal Year Final Research Report
A basic study for Application to treatment of the refractory glomerulonephritis using CD26
| Project/Area Number |
20790600
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KOBAYASHI Seiji Jikei University School of Medicine, 医学部, 助教 (80408400)
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| Project Period (FY) |
2008 – 2009
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| Keywords | CD26 / 難治性糸球体腎炎 / lipid rafts |
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| Research Abstract |
CD26 has an important role in T-cell activation and is costimulatory molecule. We demonstrated that the expression level of lipid rafts to the peripheral blood T cell surface increased over time by costimulation of CD3 and CD26. Moreover, anti CD26 antibody treatment of peripheral blood T cells led to increased surface expression of Lipid rafts. On the other hand, after costimulation under the immunosuppressive drugs treatment, the expression of lipid rafts on T cells decreases drugs concentration-dependently and over time with T-cell proliferation being inhibited. Our results suggest that lipid rafts may become the biomarker when we evaluate the effect of the immunosuppressive drug in patients with glomerulonephritis.
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