2009 Fiscal Year Final Research Report
Investigation into the role of hypothalamic SIRT1 in regulating energy metabolism.
| Project/Area Number |
20790637
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
SASAKI Tsutomu Gunma University, 生体調節研究所, 助教 (50466687)
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| Project Period (FY) |
2008 – 2009
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| Keywords | SIRT1 / 視床下部 / 食欲 |
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| Research Abstract |
Sirt1 links the energy availability status with cellular metabolism in peripheral organs. Insulin and leptin signaling regulate food intake in the arcuate nucleus of the hypothalamus. Sirt1 has been reported to improve insulin sensitivity in vitro, but the role of hypothalamic Sirt1 in regulating feeding has not been addressed. We found that hypothalamic Sirt1 protein level and stability is regulated by food intake. Forced expression of wild-type Sirt1 in the mediobasal hypothalamus suppressed hyperphagia and weight gain by suppressing the expression of the orexigenic neuropeptide AgRP.
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