2009 Fiscal Year Final Research Report
Investigation into the apoptotic signal of lymphocyte via Siva-1
| Project/Area Number |
20790678
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
SHIMODA Haruko University of Miyazaki, 医学部, 医員 (10452921)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 血液腫瘍学 / アポトーシス |
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| Research Abstract |
Tyk2 is essential for B cell growth inhibition by IFN-α. We found that Tyk2 interacts with and phosphorylates Siva-1. Siva-1 is a proapoptotic protein, and the interaction between Tyk2 and Siva-1 augmented Siva-1-induced apoptosis in Ba/F3 cells (murine pro-B cells). These observations suggest that Siva-1 forms a functional complex with Tyk2 and participates in the transduction of apoptotic signals of lymphocyte.
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