2010 Fiscal Year Final Research Report

Integrated analysis of geriatric depression: EEG/ERP and MRI studies.

Research Project

Project/Area Number	20790835
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	Mie University
Principal Investigator	MATSUMOTO Takuya Mie University, 医学部附属病院, 助教 (40437108)
Project Period (FY)	2008 – 2010
Keywords	海馬 / 高齢うつ病 / 事象関連電位 / 脳波 / P3
Research Abstract	The aim of this study is to establish temporal slow waves on electroencephalography (EEG) as a biomarker for geriatric depression. Using dipole source modeling, this EEG pattern was found to originate from the medial temporal area in both normal and depressed subjects. In an auditory P3 study, normal subjects with this EEG pattern showed a longer P3 latency, which is originated from the hippocampus than subjects without this EEG pattern. A voxel-based morphometry study did not detect focal brain lesions associated with this EEG pattern. Thus, this EEG pattern may indicate dysfunction of the medial temporal region with little morphological abnormalities. Geriatric depressive subjects with this EEG pattern showed a decrease in the left hippocampal volume compared to normal subjects with this EEG pattern. In this subgroup of geriatric depression, the hippocampal region may be involved in developing depression.

(1 results)