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2011 Fiscal Year Final Research Report

Evaluation of a radiosensitizing effect of photosensitizer for malignant gliomas

Research Project

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Project/Area Number 20791024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YAMAMOTO Junkoh  産業医科大学, 医学部, 准教授 (80461565)

Project Period (FY) 2008 – 2011
Keywordsphotodynamic therapy(PDT) / photodynamic diagnosis(PDD) / 放射線治療 / glioma / free radical
Research Abstract

Photosensitizer, such as 5-Aminolevulinic acid(ALA), are used in photodynamic therapy and fluorescence-guided resection of malignant brain tumours due to its high cellular uptake in tumours. In the present study, the possible use of 5-ALA as a radiosensitizer for malignant brain tumours is examined in vitro using rat glioma cell lines(9L, C6). 5-ALA functions as a specific radiosensitizer for malignant gliomas. Intracellular 5-ALA-induced PpIX plays an important role in the production of ROS and the radiosensitizing effect under ionizing irradiation conditions.

  • Research Products

    (3 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro2012

    • Author(s)
      Yamamoto J, et al.
    • Journal Title

      Oncol Rep

    • DOI

      DOI:10.3892/or.2012.1699.

    • Peer Reviewed
  • [Presentation] Evaluation of a radiosensitizing effect of 5-aminolevlunic acid for malignant gliomas2011

    • Author(s)
      Yamamoto J, Saito T, Takahashi M, Nishizawa S
    • Organizer
      13^<th> world congress of the international photodynamic association
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      20110511-14
  • [Presentation] Singlet oxygen detection in PDT2010

    • Author(s)
      Hirano T, Kohno E, Hirakawa K, Yamamoto J, Okazaki S
    • Organizer
      The 2^<nd> Asia Japan-Korea-China Joint Symposium of Photodynamic Therapy
    • Place of Presentation
      Fukui, Japan
    • Year and Date
      2010-06-12

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Published: 2013-07-31  

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