2009 Fiscal Year Final Research Report
Analysis of Th17 axis in the pathogenesis of human rheumatoid arthritis.
| Project/Area Number |
20791032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHITOMI Hiroyuki Kyoto University, 医学研究科, 助教 (50402920)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アレルギー・喘息 / 免疫学 / ケモカイン / TH17 / 関節リウマチ |
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| Research Abstract |
IL-1β vigorously induced the production of CCL20 from FLSs of human RA and the production of CCL20 induced by TNF-α was partially attributed to a trace amount of IL-1β induced by TNF-α. The conditioned medium of IL-1β-stimulated FLSs significantly recruited CCR6+ MNCs in a CCL20 dependent manner. Interestingly, CCL20 enhanced the production of IL-6 coordinately with the stimulation of IL-17 but not with that of IFN-g. These findings imply FLSs stimulated by proinflammatory cytokines recruit CCR6+ MNCs including IL-17-producing-helper T cells into the inflamed joint, leading to the enhancement of the production of CCL20, which chemokine and IL-17 coordinately induce proinflammatory cytokines.
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[Journal Article] Mimori T. Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009
Author(s)
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T
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Journal Title
Arthritis Rheum. 60(8)
Pages: 2294-2303
Peer Reviewed
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[Journal Article] Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.2008
Author(s)
Wakasa-Morimoto C, Toyosaki-Maeda T, Matsutani T, Yoshida R, Nakamura-Kikuoka S, Maeda-Tanimura M, Yoshitomi H, Hirota K, Hashimoto M, Masaki H, Fujii Y, Sakata T, Tsuruta Y, Suzuki R, Sakaguchi N, Sakaguchi S
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Journal Title
Int Immunol 20(10)
Pages: 1331-1342
Peer Reviewed
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