2009 Fiscal Year Final Research Report
Examination of negative regulation of cytokine signals in endometriosis
| Project/Area Number |
20791153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KAMIO Masaki Kagoshima University, 大学院・医歯学総合研究科, 助教 (50381174)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 子宮内膜症 / シグナル伝達 |
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| Research Abstract |
Endometriosis occurs in about 10% of reproductive age women. The etiology of it is not clearly defined. In this study we examined the activation of two signal pathway (JAK-STAT pathway and, RAS-MAP pathway) in endometriosis. 50 of endometriosis case and 50 of control cases were examined. In 15 endometriosis patients STAT3 was activated. The age, use of NSAIDs, affection period were not related to the activation of STAT3. The activity of STAT3 was slightly lower in a preoperative Gn-RHa administrated group. No obvious tendency was fined in MAP pathway.
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