2009 Fiscal Year Final Research Report
Analysis of immune escape mechanism in cervical cancer that aims at immunotherapeutic application
| Project/Area Number |
20791163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
NISHIO Hiroshi Keio University, 医学部, 助教 (90445239)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 子宮頸癌 / 腫瘍免疫学 / 免疫逃避 / B7ファミリー |
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| Research Abstract |
Immune suppressive molecules including PD-L1 and B7-DC was evaluated in cervical cancer cell lines by ELISA or FACS method. Activation of intracellular signaling pathways was detected by western blotting method. As a result, PD-L1 and B7-DC protein in SKGII cells was depend on Erk1/2 cascade specifically and not associated with HPV E6/E7 protein.
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