2009 Fiscal Year Final Research Report
The effect of MCP-1 on the pathogenesis of giant papillae formation of the conjunctiva in vernal keratoconjunctivitis
| Project/Area Number |
20791255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUJITSU Youichiro Yamaguchi University, 大学院・医学系研究科, 助教 (80448290)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 春季カタル / 巨大乳頭 / MCP-1 |
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| Research Abstract |
Vernal keratoconjunctivitis is characterized by giant papilla formation. Increased expression of MCP-1 was also reported in the conjunctiva of patients with vernal keratoconjunctivitis. Human conjunctival fibroblasts express CCR2, and MCP-1 stimulates both the proliferation of and the production of extracellular matrix proteins such as fibronectin, procollagen type I C-peptide and type III collagen, in the dose dependent manner by these cells through MAPK pathway.
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