Group A streptococci translocates across epithelial barrier via intercellular junction cleavage

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791336
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: SUMITOMO Tomoko Osaka University, 大学院・歯学研究科, 助教 (50423421)
• Project Period (FY): 2008 – 2009
• Keywords: レンサ球菌 / 病原因子 / 組織侵入 / 細胞間隙 / 上皮バリア

Research Abstract

Group A Streptococcus pyogenes (GAS) is a human pathogen that causes local suppurative infections and severe invasive diseases. Systemic dissemination of GAS is initiated by bacterial penetration of the epithelial barrier of the pharynx or damaged skin. In this study, our data indicate a potential function of Streptolysin S that facilitates GAS invasion into deeper tissue via degradation of epithelial intercellular junctions in concert with the host cysteine protease calpain.

Research Products

• [Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion (2010)
  • Author(s): Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.
  • Journal Title: Biochem Biophys Res Commun 391(2) Pages: 1192-1196
• [Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. (2009)
  • Author(s): Nakata M, Koller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B.
  • Journal Title: Infect Immun 77(1) Pages: 32-44
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの解析 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20100327-20100329
• [Presentation] A群レンサ球菌の上皮バリア突破機構に関与する宿主プロテアーゼの検索 (2010)
  • Author(s): 住友倫子, 中田匡宣, 東野美晴, 寺尾豊, 川端重忠
  • Organizer: 第7回感染症沖縄フォーラム
  • Place of Presentation: 沖縄国民年金健康センター.
  • Year and Date: 20100211-20100213
• [Presentation] Group A Streptococci translocates across epithelial barrier via intercellular junction cleavage. (2009)
  • Author(s): Sumitomo T, Nakata M, Terao Y, Kawabata S.
  • Organizer: 109th General Meeting of American Society for Microbiology.
  • Place of Presentation: Philadelphia, USA.
  • Year and Date: 20090517-20090521
• [Remarks]
  • URL: http://web.dent.osaka-u.ac.jp/~mcrbio/