Regulation of bone and cartilage destruction via RANKL/Fassignaling crosstalk in temporomandibular joint.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20791579
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: IZAWA Takashi The University of Tokushima, 大学院・ヘルスバイオサンエンス研究部, 助教 (30380017)
• Project Period (FY): 2008 – 2009
• Keywords: RANKLシグナル / Fasシグナル / 樹状細胞 / 関節リウマチ / 関節骨・軟骨破壊 / アポトーシス / T細胞 / TRAILシグナル

Research Abstract

The aim of this study was to analyze the effect of dedritic cells (DCs) transfer stimulated with RANKL on the development. of murine autoimmune arthropathy. Three times of RANKL-stimulated DCs transfer into arthritis model mice increased the T cell apoptosis in vivo, and protected the development of autoimmune arthritis. These data indicate that RANKL pathway plays a crucial role for immunomodulation of murine autoimmune arthropathy.

Research Products

• [Journal Article] RANKLとFasシグナルクロストークによる樹状細胞の機能調節機構 (2009)
  • Author(s): 井澤俊、石丸直澄、田中栄二、林良夫
  • Journal Title: 臨床免疫・アレルギー科 52 Pages: 471-477
• [Journal Article] Biomechanical and biochemical characteristics of the mandibular condylar cartilage (2009)
  • Author(s): Shingo Kuroda, Kotaro Tanimoto, Takashi Izawa, Shinji Fujihara, J H. Koolstra, Eiji Tanaka
  • Journal Title: Osteoarthritis and cartilage 17 Pages: 1408-1415
  • Peer Reviewed
• [Journal Article] Analysis of gene expression profiles in human periodontal ligament cells under hypoxia: the protective effect of CC chemokine ligand 2 to oxygen shortage (2009)
  • Author(s): Yukiko Kitase, Masahiko Yokozeki, Shinji Fujihara, Takashi Izawa, Shingo Kuroda, Kotaro Tanimoto, Keiji Moriyama, Eiji Tanaka
  • Journal Title: Archives of oral biology 54 Pages: 618-624
  • Peer Reviewed
• [Journal Article] Langenbach E J G and Kazuo Tanne Regional differences in fiber characteristics in the rat temporalis muscle (2008)
  • Author(s): Eiji Tanaka, Ryo Sano, Nobuhiko Kawai, Korfage A M J, Saika Nakamura, Takashi Izawa
  • Journal Title: Journal ofanatomy 213 Pages: 743-748
  • Peer Reviewed
• [Presentation] Immunoregulatory effect via RANKL and Fassignaling of dendritic cells in immurine autoimmune arthritis models (2009)
  • Author(s): Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Ritsuko OURA, Eiji Tanaka, Yoshio Hayashi
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Immune Regulation by Macrophages through cross-talk between Fas and NF-kBSignaling (2009)
  • Author(s): Ritsuko OURA, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Takashi Izawa, Kazuma Matsumoto, Eiji Tanaka, Yoshio Hayashi
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] RANKLシグナルを介した関節リウマチモデルマウスの骨・軟骨破壊機構の解析 (2009)
  • Author(s): 松本一真, 井澤俊, 田中栄二
  • Organizer: 日本顎関節学会総会・学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-26
• [Presentation] RANKL/Fasシグナルを介した関節リウマチモデルマウスの骨・軟骨破壊機構の解析 (2009)
  • Author(s): 松本一真, 井澤俊, 大浦律子, 田中栄二
  • Organizer: 日本矯正歯科学会・学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-01-18
• [Presentation] Analysis of RANKL and Fas signaling through NF-kB in dendritic cell activation in murine autoimmune arthritis models (2008)
  • Author(s): 井澤俊, 石丸直澄, 新垣理恵子, 大浦律子、田中栄二, 林良夫
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] RANKLシグナルを介した関節リウマチにおける関節骨・軟骨破壊機構の解析 (2008)
  • Author(s): 井澤俊, 林良夫, 田中栄二
  • Organizer: 第67回日本矯正歯科学会学術大会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-18