2009 Fiscal Year Final Research Report
Analysis of Wnt5a for alveolar bone resorption by periodontal disease.
| Project/Area Number |
20791624
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
ISHIHARA Akihiro Matsumoto Dental University, 歯学部, 助手 (90460419)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 破骨細胞 / Wnt / 非古典経路 |
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| Research Abstract |
This study demonstrated that Wnt5a enhances RANK ligand-induced osteoclast differentiation and resorption pit formation through the receptor Ror2 in osteoclast precursors and mature osteoclast, respectively. RT-PCR analysis showed that Wnt5a mRNA was strongly expressed in both osteoblasts and osteoclasts. RANK ligand-stimulated osteoclast formation and pit formation were enhanced by the treatment with Wnt5a. This enhancement effect of Wnt5a on osteoclast formation was dose-dependently suppressed by sRor2. sRor2 also inhibited the pit-forming activity of osteoclasts in a dose-dependent manner. These results suggest that GST-sRor2 acts as a decoy receptor of Wnt5a. Wnt5a represents a novel therapeutic target for periodontal disease.
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[Journal Article] Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009
Author(s)
Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
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Journal Title
Nano Lett 9(4)
Pages: 1406-13
Peer Reviewed
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