2009 Fiscal Year Final Research Report
Investigation on Newly Synthetic Pulmonary Surfactant from the Biophysical Aspect
| Project/Area Number |
20810041
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nanomaterials/Nanobioscience
|
|---|
| Research Institution | Nagasaki International University |
|---|
Principal Investigator |
NAKAHARA Hiromichi Nagasaki International University, 薬学部・薬学科, 助教 (00513235)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部・薬学科, 教授 (10117129)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 表面・界面物性 / 複合材料 / 肺サーファクタント / ナノ医薬 / 超薄膜 |
|---|
| Research Abstract |
As a result of in vitro and in vivo examinations, our pulmonary surfactant preparations show the similar effect to Surfacten. In addition, an electrostatic interaction between PG (phosphatidylglycerol) and peptide (Hel 13-5) prevents irreversible transformation for the peptide from α-helix to β-sheet structures.
|
