2009 Fiscal Year Final Research Report
Study of the microRNA pathway controlling developmental timing : Utilization of the amyloid precursor protein-like gene
| Project/Area Number |
20870005
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NIWA Ryusuke University of Tsukuba, 大学院・生命環境科学研究科, 助教 (60507945)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 発生・分化 / 発現制御 / 線虫 / 発生タイミング / マイクロRNA / 転写因子 / 核内受容体 |
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| Research Abstract |
The development of multicellular organisms is tightly regulated under a precise time schedule. To unravel the molecular mechanisms underlying developmental timing in multicellular organisms, I used the nematode Caenorhabditis elegans as the model organism. I identified and characterized genes involved in the let-7 microRNA pathway, which is essential for the larva-to-adult transition. I found that the nuclear receptor gene nhr-25 plays a crucial role in the developmental fate switch from larval to adult stages in C.elegans.
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