2023 Fiscal Year Final Research Report
Local hydration measured by 3D scanning AFM and elucidation of the mechanism of enhancement and suppression of hydrophobic interactions
| Project/Area Number |
20H02689
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 32010:Fundamental physical chemistry-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
生越 友樹 京都大学, 工学研究科, 教授 (00447682)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 原子間力顕微鏡 / 疎水性相互作用 / 水和構造 |
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| Outline of Final Research Achievements |
Using 3D scanning AFM technique, the hydrophobic planar model of hydrophobic structure with varying densities of immobilised ions can be visualized, revealing the influence of hydrophobic structure and ion density/ion configuration on the hydration structure. Furthermore, as a hydrophobic space model, the self-assembled structure of tetrapod-type molecules and the characteristic attraction distribution originated from the water density in the nanospace of cyclic molecules can be discussed quantitatively. The hydrophobic structure and the surrounding hydration structure can be visualised at the single-molecule level, advancing our understanding of the mechanisms of enhancement and suppression of hydrophobic interactions.
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| Free Research Field |
ナノ計測
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| Academic Significance and Societal Importance of the Research Achievements |
疎水性相互作用は化学・材料・生物・医療などざまざまな分子システムにおいて重要な相互作用であると考えられており、その分子スケールメカニズムの理解は極めて重要である。本研究の推進により進展した疎水性相互作用と局所水和構造の関係性を理解することはこれらの基礎研究・産業応用のあらゆる分野にも貢献する成果であり、学術的・社会的な両面で意義があると考えられる。3D-AFM手法で得られる微視的理解は実際の材料・分子システムの性能向上に向けた精密分子設計に貢献できる。
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