2020 Fiscal Year Annual Research Report
電気インピーダンスによる流路内の血球検査とマラリア検出への応用
| Project/Area Number |
20J10046
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| Research Institution | Chiba University |
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Principal Investigator |
TRAN ANH KIET 千葉大学, 融合理工学府, 特別研究員(DC2)
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| Project Period (FY) |
2020-04-24 – 2022-03-31
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| Keywords | Malaria / EIS / Single cell / Lung diseases |
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| Outline of Annual Research Achievements |
1.Study proposes a novel iRBCs detection method based on 3D multi-shell dielectric model
2.The electric field analysis is performed under control RBC (parasitemia p = 0%) as reference and iRBCs (p = 0.04% to 0.4%). As a result, the electric field analysis results show that the 3D multi-shell dielectric model is applicable to detect iRBCs of parasitemia p with maximum error of 0.056.
3.3D multi-shell dielectric model describes the dielectric properties of iRBCs as a function of parasitemia p to estimate p from the dielectric properties obtained from electrical impedance spectra.
4.Also I proposed the development of a biosensor system for high accuracy single cell identification as well as inspire the development of a diagnostic device for early fetal lung diseases based on the neEIS system.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The research progress is as expected. The study focuses on the dielectric properties of iRBCs as a function of parasitemia p to estimate p from the dielectric properties obtained from electrical impedance spectra. The research goal plans are achieved.
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| Strategy for Future Research Activity |
The clinical study will concentrate on intense analytical validation with a lab on chip CD type EIS hardware which was made in year 2020 in Takei lab by using malaria parasite-infected primates conducted in collaboration with Chiba University Hospital further limited field testing at Chiba University Hospital in Japan.
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| Remarks |
http://www.em.eng.chiba-u.jp/~takei/papers.html
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Research Products
(3 results)
