Basic analysis of mechanism on normalization of hyperglycemia in diabetic model mice by intestinal tapeworm

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06460
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42040:Laboratory animal science-related
• Research Institution: Nagoya University
• Principal Investigator: Ohno Tamio 名古屋大学, 医学系研究科, 准教授 (90293620)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 膜様条虫 / 糖尿病マウス / GLP1 / 短鎖脂肪酸 / ゲノム編集

Outline of Final Research Achievements

Infection of diabetic mouse models with intestinal tapeworm (Hymenolepis microstoma: Hm) normalizes hyperglycemia, but the mechanism is unknown. In this study, we focused on incretin (GLP1) and short-chain fatty acids. The results revealed that activation of GLP1 signaling is involved in the normalization of hyperglycemia, although short-chain fatty acids and the intestinal bacteria that produce them are not involved. On the other hand, it was suggested that there are other factors that normalize hyperglycemia. One of the possible factors was that Hm infection induced liver damage in mice.

Free Research Field

実験動物学

Academic Significance and Societal Importance of the Research Achievements

最近、寄生蠕虫の宿主への免疫修飾作用を応用した蠕虫療法が着目されている。本研究では膜様条虫は免疫系とは関係なくGLP1シグナルを介してマウスの高血糖を正常化させる作用がある事を明らかにした。GLP1分泌を促進する膜様条虫の虫体や虫体分泌物が判明すれば、糖尿病治療薬の開発に繋がる可能性がある。