2022 Fiscal Year Final Research Report
Regulatory mechanism of gastrointestinal motility by circadian rhythms
Project/Area Number |
20K06714
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 44040:Morphology and anatomical structure-related
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Research Institution | Saitama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
坂田 一郎 埼玉大学, 理工学研究科, 教授 (80610831)
竹見 祥大 埼玉大学, 理工学研究科, 助教 (70871440)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 消化管運動 / サーカディアンリズム / ホルモン / 時計遺伝子 / スンクス |
Outline of Final Research Achievements |
The purpose of this study was to clarify the relationship between circadian rhythms and gastrointestinal motility. We found that mRNA expression of ghrelin, a stomach derived hormone important for the gastric motility, exhibited diurnal variation and was regulated by the clock gene REV-ERB. We also found that colonic motility is affected by restricted feeding, and that the expression of the clock gene in colon was also fluctuated. We also revealed that vagal and sympathetic nerves were involved in the diurnal rhythm of colonic motility. The results of this study are expected to contribute to our understanding of the diurnal rhythm of gastrointestinal motility.
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Free Research Field |
消化管生理学
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、消化管運動を制御するホルモン及び自律神経と、時計遺伝子や摂食との関連について新しい知見を得た。これまで、時差ボケやナイトワーカーのヒトでの消化管運動機能不調の原因は明らかではなかったが、本研究によって基盤的知見を得ることができたことは、当該分野において学術的意義が高いと考えられる。また、今後トランスレーショナル研究に展開していくことで、ヒトの消化管機能疾患患者に対する治療法や薬剤の開発につながることが期待される。
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