2023 Fiscal Year Final Research Report
Understanding Intractable Fungal Airway Allergy: Pathogenesis and Therapeutic Development
Project/Area Number |
20K08577
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53030:Respiratory medicine-related
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Research Institution | Tokai University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | アレルギー性気管支肺真菌症 / アレルギー性気管支肺アレルギー症 / アスペルギルス / 真菌 / IL-1α / 光触媒 / 酸化チタン |
Outline of Final Research Achievements |
This study focused on molecules produced by airway epithelial cells directly exposed to fungi, contributing to the pathogenesis of allergic bronchopulmonary aspergillosis (ABPA). IL-1α, identified as relevant in both in vitro and in vivo models, was expressed in airway epithelial cells via a fungal antigen protease-dependent pathway involving the EGF receptor, partially mediated by TNF-α converting enzyme (TACE). Inhibiting fungal antigen protease activity through titanium dioxide photocatalytic reaction was found to be beneficial for suppressing airway allergy-related molecules of epithelial origin, such as IL-1α, similar to EGF receptor and TACE inhibitors.
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Free Research Field |
アレルギー学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、アレルギー性気管支真菌症(ABPM)の病態に関与する分子として、IL-1αを同定し、EGF受容体・TACE阻害薬と同様に、酸化チタンの光触媒反応による真菌アレルゲンの無害化がIL-1α等の気道上皮由来の気道アレルギー疾患関連分子の抑制に有用と考えられた。真菌アレルゲンの無毒化は今後、真菌アレルギーの症状の軽減・重症化予防の他、発症予防にもつながることが推測され、本研究の成果はその基礎的研究として有用と考えられた。
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