2022 Fiscal Year Final Research Report
Study of evidence based Overdose detoxification treatment using intravenous lipid emulsion
| Project/Area Number |
20K09271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤田 友嗣 岩手医科大学, 医学部, 講師 (50721974)
佐塚 泰之 岩手医科大学, 薬学部, 教授 (90162403)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 解毒治療 / 脂肪乳剤 / ILE / overdose / 救急 |
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| Outline of Final Research Achievements |
The purpose is to clarify the mechanism of intravenous lipid emulsion (ILE), which is used as a detoxification treatment for patients who have been poisoned by overdose.
The results of a mouse study on the behavior of amitriptyline (Ami) in the body after combined administration of ILE showed that Ami concentration in the blood increased immediately after administration of ILE, while it decreased quickly in the tissues. It was suggesting that Ami was transferred into the blood by administration of ILE. The free Ami in blood was temporarily trapped by ILE and decreased, and then Ami was transferred from tissues to blood through the concentration gradient over time.
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| Free Research Field |
薬剤学
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠薬や抗不安薬を意図的に多量摂取する自傷行為の症例は増加傾向にある。薬物中毒の解毒は時間との勝負であり、服用した薬物に対する適切な処置を施すことが求められる。近年、静注用脂肪乳剤を用いた解毒治療の有用性が期待されているが、医師の経験に頼り使用されており、その作用機序が明らかになっていないことが課題である。本研究は解毒治療を適切に、より効率よく実施するために必要なエビデンスを明らかにするものであり、一人でも多くの国民の命を守ることを可能とする社会的な意義が大きい研究であると考えている。
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