Elucidation of the pathogenicity and formation process of bacterial network triggered periodontal diseases

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09934
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takeuchi Yasuo 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60396968)
• Co-Investigator(Kenkyū-buntansha): 渡辺 孝康 日本大学, 歯学部, 講師 (70725514)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 歯周炎 / Dysbiosis / 歯肉炎 / メタトランスクリプトーム解析

Outline of Final Research Achievements

A comprehensive analysis of the periodontal microbiome based on bacterial RNA revealed the differences in bacterial composition and functional activities of the microbiome according to the progression of periodontal disease. Especially in gingivitis, the co-occurrence bacterial network structure was more complex than in periodontitis. Furthermore, the dysbiotic microbiome did not necessarily recover to a healthy state even when clinical symptoms improved with periodontal treatment. This may support the fact that periodontitis is a disease with a high risk of recurrence.

Free Research Field

歯学

Academic Significance and Societal Importance of the Research Achievements

バランスを乱した病的な細菌叢が治療後も容易に元の細菌組成に戻らないことは、バイオフィルムを形成する細菌の相互作用の強固さや複雑さを我々に再認識させた。本結果は歯周病予防の重要性のほか、現行の治療法の限界を示している。一方で、ある数種の細菌は病状の進行に伴い明らかに細菌の割合が増えるといった傾向が認められたことから、新たな歯周病予防・早期治療のための細菌学的マーカーとして臨床応用が期待できる。