Clinical study of exploring for oral frailty risk biomarkers in elderly patients with diabetes-associated periodontitis

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K09957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: BANDO Mika 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10510000)
• Co-Investigator(Kenkyū-buntansha): 木戸 淳一 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (10195315) ; 稲垣 裕司 徳島大学, 病院, 講師 (50380019)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 高齢者 / 糖尿病関連歯周炎 / オーラルフレイル / 口腔機能低下症 / 唾液 / 歯肉溝滲出液 / バイオマーカー

Outline of Final Research Achievements

This clinical study aimed to explore novel biomarkers that correlate with diabetes-related periodontitis and oral hypofunction. The correlation between various examination items and biological biomarkers (oxidative stress-related: 8-OHdG, diabetes-related: AGE, inflammation-related: CPT) was examined, and the results showed that CPT in gingival crevicular exudate and 8-OHdG in saliva were significantly higher in the diabetic group. In addition, 63.8% of patients aged 65 years or older had oral hypofunction. Salivary CPT was significantly associated with the values of oral wetting degree and masticatory function in the oral function examination items, 8-OHdG with oral hygiene status and lingual lip movements, and AGE with lingual lip movements. It was suggested that biological biomarkers may be useful in the diagnosis of oral hypofunction.

Free Research Field

歯周病

Academic Significance and Societal Importance of the Research Achievements

本研究の成果から、現在の口腔機能低下症の診査項目と唾液中のバイオマーカーレベルの関連性を見出した。つまり、非侵襲的に採取することができる検体から、口腔機能低下症を診断することができる可能性を示した。このことは、今の診査項目数の削減やより簡便にオーラルフレイル（口腔の脆弱化）やフレイル（全身の虚弱化）の早期発見・早期介入を促すことができ、さらには要介護状態を遅らせ健康寿命の延伸に貢献できると考えている。