2024 Fiscal Year Final Research Report

Association between sedentary lifestyle and liver cancer development in hepatitis C patients treated with direct-acting antiviral agents

Research Project

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Project/Area Number	20K10713
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 58060:Clinical nursing-related
Research Institution	University of Miyazaki
Principal Investigator	KANAOKA MAKI 宮崎大学, 医学部, 准教授 (50507796)
Co-Investigator(Kenkyū-buntansha)	永田賢治宮崎大学, 医学部, 准教授 (00372798) 木下由美子宮崎大学, 医学部, 教授 (30432925) 柳田俊彦宮崎大学, 医学部, 教授 (60295227) 中尾久子第一薬科大学, 看護学部, 教授 (80164127) 藤田君支九州大学, 医学研究院, 教授 (80315209)
Project Period (FY)	2020-04-01 – 2025-03-31
Keywords	肝臓がん / サルコペニア / ライフスタイル / 周術期看護
Outline of Final Research Achievements	This study was initially planned to examine changes in physical activity and fatigue before and after direct-acting antiviral (DAA) therapy in patients with liver disease caused by hepatitis C virus (HCV). However, the focus was revised to report findings on the preoperative status of patients with liver cancer. We conducted a multifaceted evaluation of physical activity, fatigue, presence of sarcopenia, and physical function in patients with HCV-related hepatocellular carcinoma scheduled for liver resection. Greater fatigue was observed in patients with lower grip strength and lower limb muscle strength, and a significant association with sarcopenia was identified. The findings highlight the necessity of preoperative interventions and provide fundamental data for building comprehensive perioperative support systems.
Free Research Field	臨床看護学
Academic Significance and Societal Importance of the Research Achievements	本研究は、肝臓がんで肝切除を予定する患者を対象に、術前の身体機能、倦怠感、サルコペニアの有無を多面的に評価し、これらの関連性を明らかにした点で学術的意義が高い。従来「安静」が重視されてきた肝疾患患者においても、術前の適切な身体活動や介入の重要性を示すことで、リハビリテーション・栄養・看護を含む周術期支援体制の在り方に新たな視点を提供する。さらに本研究の成果は、術後の合併症予防や再発抑制、QOL維持といった社会的課題の解決にも寄与する可能性があり、高齢化社会におけるがん患者支援の実践的エビデンスとしても意義深い。