Elucidation of intestinal environment improvement mechanism by natural wound healing material using disease mouse model

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Shimizu Miho 東京農工大学, 工学(系)研究科(研究院), 客員准教授 (00500399)
• Co-Investigator(Kenkyū-buntansha): 藤田 恵理 東京農工大学, 工学(系)研究科(研究院), 研究員 (50466877) ; 跡見 順子 東京農工大学, 工学(系)研究科(研究院), 客員教授 (90125972)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 卵殻膜 / 炎症性腸疾患 / 細胞外マトリクス / III型コラーゲン

Outline of Final Research Achievements

Chicken eggshell membrane has been described as having wound-healing effects in pharmacological books dating back more than 400 years. Recently, it has been reported that eggshell membrane improves knee joint pain and prevents fibrosis and inflammation in animals. We have found that when humans ingest eggshell membrane as a supplement, the balance of intestinal microflora improves as well as respiratory function, skin elasticity, and locomotor function, and when mice are fed eggshell membrane as a supplement, the expression of soft type III collagen, which is secreted early in the wound healing process, increases The results were obtained. In this study, the intestinal environment improving effect of eggshell membrane leading to prevention was verified by the DSS colitis mouse model by prior ingestion of eggshell membrane.

Free Research Field

健康科学

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患（IBD）は様々な腸の病気を含み、その中でも最も一般的なものは潰瘍性大腸炎（UC）とクローン病（CD）であり、持続性あるいは反復性の下痢、腹痛、血便などを伴う。近年、IBD患者は増えてきており、比較的若い年齢層（10～30歳代）で発症するため、栄養の吸収障害から成長障害をきたす可能性がある。本研究ではIBDのモデルとして最もよく用いられているDSS大腸炎モデルへの卵殻膜１日1回サプリメント的摂取が、病態悪化を防ぐ予防効果があることを示せた意義は大きい。